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Long non-coding RNA ANRIL and its target microRNAs (microRNA-34a, microRNA-125a and microRNA-186) relate to risk stratification and prognosis in multiple myeloma

by MM360 Staff | Jun 10, 2021 | Publications

Hematology. 2021 Dec;26(1):160-169. doi: 10.1080/16078454.2021.1872275.ABSTRACTOBJECTIVE: This study aimed to investigate the correlations of long non-coding RNA ANRIL (lncRNA ANRIL), microRNA (miR)-34a, miR-125a and miR-186 with disease risk, clinical features and...

Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns

by MM360 Staff | Jun 10, 2021 | Publications

Ann Hematol. 2021 Jun;100(6):1537-1546. doi: 10.1007/s00277-021-04447-6. Epub 2021 Feb 11.ABSTRACTExtramedullary disease (EMD) represents a high-risk state of multiple myeloma (MM) associated with poor prognosis. While most anti-myeloma therapeutics demonstrate...

CAR T-cell therapy for multiple myeloma: state of the art and prospects

by MM360 Staff | Jun 10, 2021 | Publications

Lancet Haematol. 2021 Jun;8(6):e446-e461. doi: 10.1016/S2352-3026(21)00057-0.ABSTRACTChimeric antigen receptors (CAR) are fusion proteins containing an antigen-recognition domain coupled to a T-cell activation domain (eg, CD3ζ [CD247]) and to a costimulatory domain...

Dynamics of minimal residual disease in patients with multiple myeloma on continuous lenalidomide maintenance: a single-arm, single-centre, phase 2 trial

by MM360 Staff | Jun 10, 2021 | Publications

Lancet Haematol. 2021 Jun;8(6):e422-e432. doi: 10.1016/S2352-3026(21)00130-7.ABSTRACTBackground Lenalidomide maintenance improves progression-free survival for patients with multiple myeloma, although its optimal duration is unknown. Clearance of minimal residual...

Feasibility of six cycles of lenalidomide-based triplet induction before stem cell collection for newly diagnosed transplant-eligible multiple myeloma

by MM360 Staff | Jun 10, 2021 | Publications

Hematology. 2021 Dec;26(1):388-392. doi: 10.1080/16078454.2021.1926101.ABSTRACTOBJECTIVES: Achieving a deep response with induction therapy has a major impact on outcomes following autologous stem cell transplantation. Although longer and intensified induction therapy...
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