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Construction of CD138-targeted chimeric antigen receptor- modified T cells and their effect in multiple myeloma therapy

by | Jul 5, 2024 | Publications

Zhonghua Xue Ye Xue Za Zhi. 2024 May 14;45(5):436-444. doi: 10.3760/cma.j.cn121090-20240131-00047. ABSTRACT Objective: To construct a novel chimeric antigen receptor T (CAR-T) cell targeting CD138 and to investigate its cytotoxicity against myeloma cells. Methods: The...

Correlation analysis of polyclonal plasma cell proportion in the bone marrow with clinical characteristics of patients with newly diagnosed multiple myeloma

by | Jul 5, 2024 | Publications

Zhonghua Xue Ye Xue Za Zhi. 2024 May 14;45(5):475-480. doi: 10.3760/cma.j.cn121090-20231020-00221. ABSTRACT Objective: To explore the correlation of bone marrow polychonal plasma cell proportion (pPC% ) and clinical features in newly diagnosed multiple myeloma (NDMM)...

Retrospective clinical study on cryopreservation-free integrated autologous hematopoietic stem cell transplantation model for newly diagnosed multiple myeloma

by | Jul 5, 2024 | Publications

Zhonghua Xue Ye Xue Za Zhi. 2024 May 14;45(5):488-494. doi: 10.3760/cma.j.cn121090-20230929-00152. ABSTRACT Objective: To explore the efficacy and safety of cryopreservation-free integrated autologous hematopoietic stem cell transplantation (HSCT) model for patients...

Gastric and colic digestive localizations of myeloma; 3 case studies and literature review

by | Jul 5, 2024 | Publications

Ann Pathol. 2024 Jul 3:S0242-6498(24)00129-9. doi: 10.1016/j.annpat.2024.06.007. Online ahead of print. ABSTRACT Multiple myeloma is a malignant plasma cell proliferation located in the bone marrow and bones. It can secondarily manifest with extraosseous involvement,...

Clotrimazole inhibits growth of multiple myeloma cells in vitro via G0/G1 arrest and mitochondrial apoptosis

by | Jul 5, 2024 | Publications

Sci Rep. 2024 Jul 4;14(1):15406. doi: 10.1038/s41598-024-66367-5. ABSTRACT Patients with multiple myeloma (MM) experience relapse and drug resistance; therefore, novel treatments are essential. Clotrimazole (CTZ) is a wide-spectrum antifungal drug with antitumor...

Acute hypoxic respiratory failure due to Lenalidomide-induced interstitial pneumonitis in a patient with multiple myeloma

by | Jul 5, 2024 | Publications

BMC Pulm Med. 2024 Jul 4;24(1):321. doi: 10.1186/s12890-024-03129-z. ABSTRACT BACKGROUND: Patients with multiple myeloma are immunosuppressed due to both the disease itself and immunosuppressive therapies. Thus, when presenting with respiratory failure and pulmonary...
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