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A comparative analysis of transcriptomics of newly diagnosed multiple myeloma: exploring drug repurposing

by | May 1, 2024 | Publications

Front Oncol. 2024 Apr 16;14:1390105. doi: 10.3389/fonc.2024.1390105. eCollection 2024. ABSTRACT Multiple myeloma (MM) is an incurable malignant plasma cell disorder characterized by the infiltration of clonal plasma cells in the bone marrow compartment. Gene...

Progression-free survival as a surrogate endpoint for overall survival in patients with relapsed or refractory multiple myeloma

by | Apr 30, 2024 | Publications

BMC Cancer. 2024 Apr 29;24(1):541. doi: 10.1186/s12885-024-12263-0. ABSTRACT OBJECTIVES: The goal of the research was to assess the quantitative relationship between median progression-free survival (PFS) and median overall survival (OS) specifically among patients...

Plasmablastic myeloma transformation of light-chain multiple myeloma

by | Apr 30, 2024 | Publications

J Clin Exp Hematop. 2024 Apr 30. doi: 10.3960/jslrt.24004. Online ahead of print. ABSTRACT Plasmablastic myeloma (PBM) is an uncommon and aggressive morphologic variant of multiple myeloma (MM). The neoplastic immature cells exhibit diverse morphology, posing a...

The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression

by | Apr 30, 2024 | Publications

Blood Cancer J. 2024 Apr 29;14(1):74. doi: 10.1038/s41408-024-01053-3. ABSTRACT Smoldering multiple myeloma (SMM) precedes multiple myeloma (MM). The risk of progression of SMM patients is not uniform, thus different progression-risk models have been developed,...

Implementing multi-level network meta-regression for time-to-event outcomes: A case study in relapsed refractory multiple myeloma

by | Apr 29, 2024 | Publications

Value Health. 2024 Apr 26:S1098-3015(24)02349-0. doi: 10.1016/j.jval.2024.04.017. Online ahead of print. ABSTRACT OBJECTIVES: Multi-level network meta-regression (ML-NMR) leverages individual patient data (IPD) and aggregate data (AD) from a network of randomized...

Recent advances in the treatment and prevention of peripheral neuropathy after multiple myeloma treatment

by | Apr 29, 2024 | Publications

Ibrain. 2023 Sep 6;9(4):421-430. doi: 10.1002/ibra.12132. eCollection 2023 Winter. ABSTRACT The incidence of multiple myeloma (MM) is increasing year by year, requiring chemotherapy drugs to control the condition. With the advent of new proteasome inhibitors,...
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